Bioidentical vs. Synthetic Estrogens

Synthetic or non-bioidentical conjugated equine estrogens (CEE), derived from the urine of pregnant mares, is molecularly different than human hormones and can create damage to human hormone receptors resulting in negative side effects. Long-term use of CEE has been shown to increase risk of breast cancer, particularly when synthetic progestin medroxyprogesterone acetate (MPA) is added. In addition, synthetic non-bioidentical hormones may contribute to early elevated levels of C-reactive protein, one of the main indicators of cardiovascular events.